Do you always feel tired and drained out? It can be a sign of Multiple Sclerosis

Patients with Multiple Sclerosis often face problems with vision and complain of pain, muscle spasms, and abnormal sensations like numbness and tingling.

By Dr. Na’eem Sadiq  Published on  7 Oct 2022 3:30 AM GMT
Do you always feel tired and drained out? It can be a sign of Multiple Sclerosis

Hyderabad: Do you feel worn out and sluggish even after a good night's rest? Are you someone who always complains of exhaustion and tiredness from doing the bare minimum activities? Does your fatigue get worse as the day goes on?

If yes, then you need to render close attention to this, as it could be a sign of Multiple Sclerosis.

What is Multiple Sclerosis (MS)?

Multiple sclerosis is a disabling autoimmune disorder of the brain and the spinal cord. It mainly affects women more than men and is seen in the age group of 20-40 years.

In an autoimmune condition, the body's defence mechanisms mistakenly attack its cells. MS leads to nerve damage as the body's immune system attacks and eats away the protective layer (called the myelin sheath) of the nerves. This, in turn, alters the movement of electrical impulses thus hampering the communication between the brain and the rest of the body. Multiple Sclerosis is a progressive disorder capable of causing permanent damage to the nerves.

What are the signs of Multiple Sclerosis?

The signs and symptoms of Multiple Sclerosis vary according to the extent and severity of damage and also depend upon the type of nerves that are affected.

Patients with Multiple Sclerosis often face problems with vision and complain of pain, muscle spasms, and abnormal sensations like numbness and tingling. They also experience severe muscle weakness, fatigue, dizziness, and problems with their balance and thinking skills. Bladder issues, sexual dysfunctions, and difficulty with speech and swallowing are some of the severe symptoms of Multiple Sclerosis.

However, fatigue is the most common and disabling symptom which affects 75 to 95 percent of patients with Multiple Sclerosis.

Are Fatigue and tiredness the same?

Fatigue and tiredness are not the same. Everybody gets tired at the end of the day or after certain strenuous activities. But this usually resolves after a good night's sleep or prolonged rest. Fatigue on the other hand is not relieved by sleep. It is excessive exhaustion and unusual tiredness lasting for days to months. Sometimes, the patient feels fatigued even after waking up.

It gives a sense of lack of energy or exhaustion with reduced physical and mental energy that is said to interfere with the usual activities. Fatigue makes people feel overwhelmingly tired, with no apparent cause.

Fatigue in Multiple Sclerosis

Multiple Sclerosis related fatigue is an invisible symptom that is very difficult to cope with for those living with the disease. It is often described by some as being weighed down and feeling clumsy. While others find it to be more mental where the brain is fuzzy and they are unable to think or speak clearly.

Fatigue due to MS is of two types. It causes different problems in patients.

Ø The first type causes a feeling of lack of energy. One may feel as if you haven't slept the night before and this may worsen as the day progresses.

Ø The second one is more related to muscular fatigue due to repeated activity. It is usually noticed while walking when one drags the foot or is more unsteady.


How can we distinguish between fatigue due to Multiple Sclerosis and tiredness?

These are a few of the following characteristics of MS-related fatigue

1. It is present almost every day.

2. It comes on more easily and suddenly.

3. Most commonly experienced in the morning, even after a restful night's sleep.

4. Worsens as the day progresses.

5. Hampers the daily activities and work.

6. Often aggravated by heat and humidity.

How to proceed further?

If you or anyone you know is suffering from exhaustion or tiredness that reflects the fatigue seen in Multiple Sclerosis, along with any other symptoms mentioned in this article, consult a Neurologist. They will talk to you about your symptoms and correlate them with the clinical signs. They would also ask you to undergo a series of tests to confirm if you have Multiple Sclerosis. The current treatment options include immune-suppressant drugs, physical rehabilitation therapies such as physiotherapy and occupational therapy, and regenerative medicine or stem cell therapy.


According to a study conducted in 2019, there is convincing evidence that stem cell therapy is effective in stopping inflammatory MS activity and in helping improve neurological disability in people with MS. Another review stated that autologous stem cell therapy can suppress MS disease activity for 4–5 years in 70 to 80 percent of people with MS. The review also states that this rate is higher than any other rate achieved by other MS therapies. The 2019 review by European Bone Marrow Transplantation Registry also adds that the safety of autologous stem cell therapy has improved in recent years.

We at Plexus Neuro and Stem Cell Research Center too have seen groundbreaking results with the application of stem cell therapy in patients with Multiple Sclerosis. According to Dr. Na'eem Sadiq, Medical Director and Head of the Department of Stem cell therapy at Plexus:

"Patient comes on a wheelchair and goes back walking, there is a significant reduction in their fatigue levels and the treatment success is also reflected by their Expanded disability status scale (EDSS) score before and after treatment."

To consult for Multiple Sclerosis contact: PLEXUS Bangalore +91 89048 42087 | 080 2546 0886, 080 2547 0886, 080 2549 0886, and Hyderabad on +91 78159 64668 | 040-2406 7886.

Dr. Na'eem Sadiq, MD, PhD

Medical Director and Head of Department of Stem cell therapy

Plexus Neuro and Stem cell research center


Kanishka Sharma, MOT

Senior Occupational Therapist and Head of Department of Rehabilitation

Plexus Neuro and stem cell research center


Kajal Shivalkar, MPT, Neuro-Physiotherapist

Department of Rehabilitation

Plexus Neuro and Stem Cell Research Centre

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