Vijayawada: Lynch syndrome patient’s multiple cancers diagnosis highlights need for genetic testing
The patient, SD, was first diagnosed with breast cancer, for which she underwent surgery followed by chemotherapy and radiation therapy
By Newsmeter Network Published on 27 Feb 2025 6:40 PM IST
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Vijayawada: A woman diagnosed with Lynch syndrome—a genetic condition that increases the risk of multiple cancers—has successfully battled three different malignancies over the years. Her case highlighted the importance of genetic testing, early diagnosis and comprehensive cancer care in improving survival rates for high-risk individuals.
Genetic testing after three cancers reveals Lynch syndrome
The patient, SD, was first diagnosed with breast cancer, for which she underwent surgery followed by chemotherapy and radiation therapy. In 2019, a routine check-up led to the detection of tongue cancer, requiring another round of surgery, chemotherapy and radiation.
After years of regular follow-ups, she was diagnosed with colon cancer in 2024. A surgical procedure was performed to remove the affected part of the colon, followed by chemotherapy to reduce the chances of recurrence.
Given the occurrence of three separate cancers in a single patient, genetic testing was conducted, confirming that she had Lynch syndrome—a condition caused by mutations in genes responsible for repairing DNA errors. These mutations lead to an increased risk of cancers, particularly in the colon, uterus, ovaries and stomach.
Importance of genetic counselling
The patient’s treatment was managed at American Oncology Institute (AOI), Mangalagiri, where a team of specialists, including Dr N Subba Rao, Dr Kalyan Polavarapu, Dr Manikumar S, and Dr Eshant I developed a comprehensive multidisciplinary approach for her care.
Harish Trivedi, CEO, CTSI-South Asia, emphasised the significance of this case, stating, “This case exemplifies AOI’s commitment to providing world-class, evidence-based cancer care. The ability to successfully diagnose and treat a patient with three synchronous primary malignancies reflects the advanced capabilities of our oncology team and the importance of genetic insights in modern cancer treatment.”
Dr Kalyan Polavarapu, senior consultant for Surgical Oncology, AOI, stressed the role of genetic screening and personalised treatment, saying, “Lynch syndrome significantly increases the risk of multiple cancers. Early diagnosis and vigilant follow-up play a crucial role in improving survival rates. This case underscores the importance of personalised treatment strategies and genetic counselling for high-risk individuals.”
Genetic screening must for families
Following her latest treatment, the patient is recovering well and remains under regular follow-up to monitor her health. Her journey highlights the critical role of early detection, advanced medical care, and genetic counselling in managing hereditary cancer risks.
